rs12145418 - ESRRG
Magnitude 2.8 · 1 study on file
Reported associations
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Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. - Cancer science (2014) · Low SK, Chung S, Takahashi A, Zembutsu H, Mushiroda T, Kubo M, Nakamura Y · PubMed 23648065
Chemotherapeutic agents are notoriously known to have a narrow therapeutic range that often results in life-threatening toxicity. Hence, it is clinically important to identify the patients who are at high risk for severe toxicity to certain chemotherapy through a pharmacogenomics approach. In this study, we carried out multiple genome-wide association studies (GWAS) of 13 122 cancer patients who received different chemotherapy regimens, including cyclophosphamide- and platinum-based (cisplatin and carboplatin), anthracycline-based (doxorubicin and epirubicin), and antimetabolite-based (5-fluorouracil and gemcitabine) treatment, antimicrotubule agents (paclitaxel and docetaxel), and topoisomerase inhibitors (camptothecin and etoposide), as well as combination therapy with paclitaxel and car
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Drug interactions
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antimicrotubule drug sensitivity with oncologist Moderate
T allele carriers at rs12145418 show significantly increased risk of neutropenia and leucopenia when treated with antimicrotubule chemotherapy agents
If prescribed antimicrotubule chemotherapy, discuss this variant with your oncologist before treatment initiation to plan monitoring and dose management