rs12144699 - FGGY-DT, JUN-DT

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder - Unknown journal (n.d.) · Unknown authors · PubMed 26503763

  ABSTRACT: Lithium is the mainstay prophylactic treatment for bipolar disorder (BD), but treatment response varies considerably across individuals. Patients who respond well to lithium treatment might represent a relatively homogeneous subtype of this genetically and phenotypically diverse disorder. Here, we performed genome-wide association studies (GWAS) to identify (i) specific genetic variations influencing lithium response and (ii) genetic variants associated with risk for lithium-responsive BD. Patients with BD and controls were recruited from Sweden and the United Kingdom. GWAS were performed on 2698 patients with subjectively defined (self-reported) lithium response and 1176 patients with objectively defined (clinically documented) lithium response. We next conducted GWAS comparing

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