rs12144344 - ST6GALNAC3

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study of circulating vitamin D-binding protein. - The American journal of clinical nutrition (2015) · Moy KA, Mondul AM, Zhang H, Weinstein SJ, Wheeler W, Chung CC, Männistö S, Yu K, Chanock SJ, Albanes D · PubMed 24740207

  Vitamin D status may influence a spectrum of health outcomes, including osteoporosis, arthritis, cardiovascular disease, and cancer. Vitamin D-binding protein (DBP) is the primary carrier of vitamin D in the circulation and regulates the bioavailability of 25-hydroxyvitamin D. Epidemiologic studies have shown direct DBP-risk relations and modification by DBP of vitamin D-disease associations. We aimed to characterize common genetic variants that influence the DBP biochemical phenotype. We conducted a genome-wide association study (GWAS) of 1380 men through linear regression of single-nucleotide polymorphisms (SNPs) in the Illumina HumanHap500/550/610 array on fasting serum DBP, assuming an additive genetic model, with adjustment for age at blood collection. We identified 2 independent SNPs

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