Expressive

rs12144063 - EYA3

Magnitude 2.2 · 1 study on file

Reported associations

  • Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids - Unknown journal (n.d.) · Unknown authors · PubMed 30926973

    ABSTRACT: The concentrations of high- and low-density lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 novel loci, some of which were detected only because the association differed by smoking status. Additionally, we demonstrated the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings. Editorial summary: A multi-ancestry genome-wide gene-smoking interaction study

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • HDL cholesterol levels Moderate

    T allele associates with reduced HDL cholesterol, a key cardiovascular risk factor

    Check HDL annually; target >40 mg/dL men, >50 mg/dL women

Diet

  • Refined carbohydrates and added sugars Moderate

    Refined carbs lower HDL; reduction may improve HDL cholesterol levels

    Limit refined grains, sugary beverages, and added sugars

Discuss with your doctor

  • Cardiovascular risk assessment with physician Moderate

    T allele associates with increased risk of stroke, warranting clinical evaluation

    Discuss appropriate stroke prevention strategies and preventive screening

Exercise

  • Regular aerobic exercise Moderate

    Physical activity raises HDL cholesterol, offsetting genetic predisposition to lower levels

    150 minutes moderate-intensity aerobic exercise per week