Expressive

rs12140813 - ZNF678

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women - Unknown journal (n.d.) · Unknown authors · PubMed 33510174

    ABSTRACT: Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study meta-analysis of 256,523 Europeans aged 60 years and over from 22 cohorts we identify 15 loci associated with muscle weakness (European Working Group on Sarcopenia in Older People definition: n = 48,596 cases, 18.9% of total), including 12 loci not implicated in previous analyses of continuous measures of grip strength. Loci include genes reportedly involved in autoimmune disease (HLA-DQA1 p = 4 × 10−17), arthritis (GDF5 p = 4 × 10−13), cell cycle control and cancer protection, regulation of transcription, and others involved in the development and maintenance of the musculoskeletal system. Using Men

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • resistance training with grip strengthening focus Moderate

    Genetic risk for age-related grip strength decline; resistance training is evidence-based for maintaining muscle strength.

    2-3 sessions per week; include grip strengthening and progressive resistance exercises.

Screening

  • clinical evaluation for hand osteoarthritis Moderate

    Strong genetic correlation with osteoarthritis (29.7%); hand OA reduces grip strength and confounds strength as health biomarker.

    Clinical hand exam; imaging if pain or joint changes; discuss findings with clinician.

  • hand grip strength starting age 55 Moderate

    Genetic predisposition to progressive loss of grip strength in older adults; baseline and serial testing enables tracking.

    Grip strength test at age 55, repeat every 2-3 years; discuss decline with clinician.