rs12140644 - HNRNPA3P14, ADGRL2

Magnitude 2.2 · 1 study on file

Reported associations

• The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition - Unknown journal (n.d.) · Unknown authors · PubMed 41688637

  ABSTRACT: The gut microbiota is associated with human health and disease. Here we conducted a genome-wide association study of host genetic factors influencing gut microbiota composition in 12,652 individuals from the Trøndelag Health Study (HUNT), with replication in Nordic cohorts (n = 16,017-21,976). We identified 12 reproducible SNP-species associations across six genomic loci, including known (LCT, ABO) and novel (HLA-DQB1, MUC12, SLC37A2, FUT2) regions. Additionally, we detected genetic signals associated with gut microbiota functional modules at three loci (LCT, ABO, FUT2). Follow-up analyses suggest that these host-microbiota associations are linked to the pathogenesis of celiac disease and hemorrhoidal disease. Mendelian randomization analyses provided evidence supporti

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