rs12137025 - CAPN8 - RNU6-1248P
Magnitude 2.2 · 1 study on file
Reported associations
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CAPN2/CAPN8 locus on chromosome 1q associated with variation in serum α-carotene concentrations - Unknown journal (n.d.) · Unknown authors · PubMed 28002826
ABSTRACT: Background/Aims Alpha-carotene is a pro-vitamin A carotenoid present in fruits and vegetables. Higher serum concentrations of α-carotene have been associated with lower risk of cancer and all-cause mortality. Previous studies have suggested that genetic variants influence serum concentrations of pro-vitamin A carotenoids, but no variants have been robustly associated with serum α-carotene concentrations to date. The aim of this study was to identify genetic associations with serum α-carotene concentrations using the genome-wide association study (GWAS) approach. Methods A GWAS of serum α-carotene concentrations was conducted in 433 Old Order Amish adults who had consumed a 6-day controlled diet. Linear regression models adjusting for age, gender, and family structure were uti
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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alpha-carotene-rich vegetables (carrots, squash) Low
rs12137025 C allele is associated with higher serum alpha-carotene, which has antioxidant properties and is inversely associated with gastric cancer, all-cause mortality, and cardiovascular disease.
Include carrots, pumpkin, squash in regular diet; aim for 1-2 servings daily