rs12135534 - PCNX2
Magnitude 4.5 · 1 study on file
Reported associations
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GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium - Unknown journal (n.d.) · Unknown authors · PubMed 27325353
ABSTRACT: Summary Decline in muscle strength with aging is an important predictor of health trajectory in the elderly. Several factors, including genetics, are proposed contributors to variability in muscle strength. To identify genetic contributors to muscle strength, a meta‐analysis of genomewide association studies of handgrip was conducted. Grip strength was measured using a handheld dynamometer in 27 581 individuals of European descent over 65 years of age from 14 cohort studies. Genomewide association analysis was conducted on ~2.7 million imputed and genotyped variants (SNPs). Replication of the most significant findings was conducted using data from 6393 individuals from three cohorts. GWAS of lower body strength was also characterized in a subset of cohorts. Two genomewide sig
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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lower body resistance training program Moderate
rs12135534-A is associated with reduced lower body strength; targeted resistance training may help offset this genetic predisposition.
3-4 sessions per week of lower body resistance exercise (squats, lunges, deadlifts, leg press)
Screening
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lower body strength assessment Moderate
rs12135534-A is associated with reduced lower body strength; periodic assessment can track functional capacity and guide training.