rs12134040 - ERO1B - EDARADD
Magnitude 2.2 · 1 study on file
Reported associations
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Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans - Unknown journal (n.d.) · Unknown authors · PubMed 25811787
ABSTRACT: We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, Pinter= 2.6 x 10-8). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDARADD, also displayed suggestive differences in main effect size between the lean and obese stra
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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serum urate level Moderate
rs12134040-G increases serum urate; effect amplified by high BMI; elevated urate raises gout and metabolic disease risk
annual fasting serum urate; increase frequency to 6-month intervals if BMI greater than 30
- GWAS_CATALOG:25811787
Lifestyle
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BMI maintenance Moderate
rs12134040 effect on urate is BMI-dependent; weight management reduces variant-related hyperuricemia risk
maintain BMI below 30 through regular activity and balanced diet
- GWAS_CATALOG:25811787