rs12133885 - DENND1B
Magnitude 2.2 · 1 study on file
Reported associations
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Uncovering myocardial infarction genetic signatures using GWAS exploration in Saudi and European cohorts - Unknown journal (n.d.) · Unknown authors · PubMed 38072966
ABSTRACT: Genome-wide association studies (GWAS) have yielded significant insights into the genetic architecture of myocardial infarction (MI), although studies in non-European populations are still lacking. Saudi Arabian cohorts offer an opportunity to discover novel genetic variants impacting disease risk due to a high rate of consanguinity. Genome-wide genotyping (GWG), imputation and GWAS followed by meta-analysis were performed based on two independent Saudi Arabian studies comprising 3950 MI patients and 2324 non-MI controls. Meta-analyses were then performed with these two Saudi MI studies and the CardioGRAMplusC4D and UK BioBank GWAS as controls. Meta-analyses of the two Saudi MI studies resulted in 17 SNPs with genome-wide significance. Meta-analyses of all 4 studies revealed 66 l
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Myocardial infarction prevention strategy Moderate
rs12133885 genetic risk warrants personalized discussion of prevention, risk modification, and screening strategy
Lifestyle
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Regular aerobic exercise Moderate
Myocardial infarction risk reduction through aerobic conditioning and improved cardiovascular function
150 minutes moderate-intensity aerobic exercise per week, or 75 minutes vigorous-intensity weekly
Screening
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Baseline cardiovascular assessment Moderate
rs12133885 is associated with increased myocardial infarction risk (OR=1.047, p=8.00e-7) in 640,268 participants
Baseline EKG, lipid panel, blood pressure assessment; discuss age-appropriate ongoing monitoring with physician