rs12133007 - LINC00303

Magnitude 4.5 · 1 study on file

Reported associations

• Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study. - The lancet. Psychiatry (2019) · Yu H, Yan H, Wang L, Li J, Tan L, Deng W, Chen Q, Yang G, Zhang F, Lu T, Yang J, Li K, Lv L, Tan Q, Zhang H, Xiao X, Li M, Ma X, Yang F, Li L, Wang C, Li T, Zhang D, Yue W · PubMed 29503163

  Antipsychotic drugs improve schizophrenia symptoms and reduce the frequency of relapse, but treatment response is highly variable. Little is known about the genetic factors associated with treatment response. We did a genome-wide association study of antipsychotic treatment response in patients with schizophrenia. The discovery cohort comprised patients with schizophrenia from 32 psychiatric hospitals in China that are part of the Chinese Antipsychotics Pharmacogenomics Consortium. Patients who met inclusion criteria were randomly assigned (1:1:1:1:1:1) to six groups (olanzapine, risperidone, quetiapine, aripiprazole, ziprasidone, and haloperidol or perphenazine; those assigned to haloperidol or perphenazine were subsequently assigned [1:1] to one or the other) for 6 weeks. Antipsychotic r

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