Expressive

rs12129838 - YWHAQP9 - RNU6-725P

Magnitude 4.5 · 1 study on file

Reported associations

  • Nightmares share genetic risk factors with sleep and psychiatric traits - Unknown journal (n.d.) · Unknown authors · PubMed 38413574

    ABSTRACT: Nightmares are vivid, extended, and emotionally negative or negative dreams that awaken the dreamer. While sporadic nightmares and bad dreams are common and generally harmless, frequent nightmares often reflect underlying pathologies of emotional regulation. Indeed, insomnia, depression, anxiety, or alcohol use have been associated with nightmares in epidemiological and clinical studies. However, the connection between nightmares and their comorbidities are poorly understood. Our goal was to examine the genetic risk factors for nightmares and estimate correlation or causality between nightmares and comorbidities. We performed a genome-wide association study (GWAS) in 45,255 individuals using a questionnaire-based assessment on the frequency of nightmares during the past month and

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Lifestyle

  • consistent sleep schedule and sleep environment optimization Moderate

    GWAS association indicates genetic predisposition to nightmare disorder; regular sleep timing and stable sleep environment reduce nightmare frequency

    maintain bedtime/wake time within 1 hour consistency, keep bedroom at 65-68F, eliminate light sources

    • GWAS_CATALOG:38413574
  • stress reduction and relaxation practices Moderate

    Stress and anxiety strongly exacerbate nightmare frequency; consistent relaxation techniques reduce occurrence in genetically predisposed individuals

    practice meditation, progressive muscle relaxation, or yoga for 15-30 minutes daily

    • GWAS_CATALOG:38413574

Screening

  • nightmare disorder assessment and history Moderate

    GWAS association with nightmare phenotype (p=7.00e-6, n=45255) indicates elevated genetic risk requiring clinical evaluation for nightmare disorder

    discuss nightmare frequency, distress level, sleep disruption impact, and treatment options with primary care or sleep specialist

    • GWAS_CATALOG:38413574