rs12128448 - ZBTB8A

Magnitude 2.2 · 1 study on file

Reported associations

• Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization. - Cell host & microbe (2024) · Fang ZY, Stickley SA, Ambalavanan A, Zhang Y, Zacharias AM, Fehr K, Moossavi S, Petersen C, Miliku K, Mandhane PJ, Simons E, Moraes TJ, Sears MR, Surette MG, Subbarao P, Turvey SE, Azad MB, Duan Q · PubMed 39293435

  The human milk microbiota (HMM) is thought to influence the long-term health of offspring. However, its role in asthma and atopy and the impact of host genomics on HMM composition remain unclear. Through the CHILD Cohort Study, we followed 885 pregnant mothers and their offspring from birth to 5 years and determined that HMM was associated with maternal genomics and prevalence of childhood asthma and allergic sensitization (atopy) among human milk-fed infants. Network analysis identified modules of correlated microbes in human milk that were associated with subsequent asthma and atopy in preschool-aged children. Moreover, reduced alpha-diversity and increased Lawsonella abundance in HMM were associated with increased prevalence of childhood atopy. Genome-wide association studies (GWASs) id

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.