Expressive

rs12127073 - SDCCAG8

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genetic variants and functional pathways associated with resilience to Alzheimer's disease - Unknown journal (n.d.) · Unknown authors · PubMed 32844198

    ABSTRACT: Why are some individuals able to tolerate severe Alzheimer's disease pathology without experiencing dementia? Dumitrescu et al. perform a large genome-wide analysis of resilience to Alzheimer's disease and highlight several biological pathways that may protect the brain from the downstream consequences of amyloidosis. Abstract Approximately 30% of older adults exhibit the neuropathological features of Alzheimer's disease without signs of cognitive impairment. Yet, little is known about the genetic factors that allow these potentially resilient individuals to remain cognitively unimpaired in the face of substantial neuropathology. We performed a large, genome-wide association study (GWAS) of two previously validated metrics of cognitive resilience quantified using a latent v

  • Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival - Unknown journal (n.d.) · Unknown authors · PubMed 33128006

    ABSTRACT: Walking is a simple form of exercise, widely promoted for its health benefits. Self-reported walking pace has been associated with a range of cardiorespiratory and cancer outcomes, and is a strong predictor of mortality. Here we perform a genome-wide association study of self-reported walking pace in 450,967 European ancestry UK Biobank participants. We identify 70 independent associated loci (P < 5 × 10−8), 11 of which are novel. We estimate the SNP-based heritability as 13.2% (s.e. = 0.21%), reducing to 8.9% (s.e. = 0.17%) with adjustment for body mass index. Significant genetic correlations are observed with cardiometabolic, respiratory and psychiatric traits, educational attainment and all-cause mortality. Mendelian randomization analyses suggest a potentia

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