rs12126004 - CTXND2 - SETDB1
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Actinic keratosis risk management with dermatologist Moderate
Strong genetic association warrants proactive specialist discussion of prevention, screening, and treatment
Lifestyle
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Prolonged unprotected sun exposure Moderate
Carriers of rs12126004 T allele have increased actinic keratosis susceptibility; UV radiation is the primary environmental risk factor
Use SPF 30+ broad-spectrum sunscreen daily, seek shade 10am-4pm, wear protective clothing
Screening
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Dermatological screening for actinic keratosis Moderate
Genetic risk variant is strongly associated with actinic keratosis; early detection prevents malignant progression
Annual skin check starting age 40, or age 30 if high sun exposure history