rs12112877 - COG5
Magnitude 2.2 · 1 study on file
Reported associations
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Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants - Unknown journal (n.d.) · Unknown authors · PubMed 36474045
ABSTRACT: The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) comprising 181,522 cases among 1,165,690 participants of predominantly European ancestry. We detected 241 associations, including 30 new loci. Cross-ancestry meta-analysis with a Japanese GWAS yielded 38 additional new loci. We prioritized likely causal variants using functionally informed fine-mapping, yielding 42 associations with less than five variants in the 95% credible set. Similarity-based clustering suggested roles for early developmental processes, cell cycle signaling and vascular cell migration and proliferation in the pathogenesis of CAD. We priorit
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Cardiovascular risk assessment and CAD screening Moderate
rs12112877 risk allele T associates with coronary artery disease in large population study (1.16M persons)
Discuss cardiovascular risk evaluation timing and testing approach with healthcare provider