rs12112389 - MINDY4 - AQP1
Magnitude 2.2 · 1 study on file
Reported associations
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GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer - Unknown journal (n.d.) · Unknown authors · PubMed 34021172
ABSTRACT: Genetic studies have examined body-shape measures adjusted for body mass index (BMI), while allometric indices are additionally adjusted for height. We performed the first genome-wide association study of A Body Shape Index (ABSI), Hip Index (HI) and the new Waist-to-Hip Index and compared these with traditional indices, using data from the UK Biobank Resource for 219,872 women and 186,825 men with white British ancestry and Bayesian linear mixed-models (BOLT-LMM). One to two thirds of the loci identified for allometric body-shape indices were novel. Most prominent was rs72959041 variant in RSPO3 gene, expressed in visceral adipose tissue and regulating adrenal cell renewal. Highly ranked were genes related to morphogenesis and organogenesis, previously additionally linked to can
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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metabolic risk from body composition genetics Moderate
Genetic predisposition to increased central adiposity associated with increased metabolic risk
Discuss at annual physical; consider preventive strategies
Screening
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waist circumference and waist-to-hip ratio Moderate
Genetic variant associated with increased waist-to-hip ratio adjusted for BMI, a marker of central adiposity and metabolic dysfunction
Measure annually or semi-annually; calculate WHR