rs12110423 - PRKN
Magnitude 2.2 · 1 study on file
Reported associations
-
Novel risk loci for COVID-19 hospitalization among admixed American populations - Unknown journal (n.d.) · Unknown authors · PubMed 39361370
ABSTRACT: The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
COVID-19 prevention strategy based on genetic risk Moderate
PRKN rs12110423 A-allele is associated with increased COVID-19 hospitalization risk in large population studies.
Discuss with physician about additional COVID-19 prevention measures (booster, antivirals, testing protocols).
Screening
-
Heightened COVID-19 testing given genetic risk Moderate
Genetic predisposition to COVID-19 hospitalization supports early detection and prompt management.
Test with respiratory symptoms or known exposure; discuss antiviral options with physician if positive.