rs12105620 - SLC19A3

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-wide association study identifies novel variants in olfactory, vitamin A, vitamin B, and cadherin pathways associated with learning and memory - Unknown journal (n.d.) · Unknown authors · PubMed 41413636

    ABSTRACT: Learning and memory, as fundamental components of human cognition, are heritable traits that are highly variable between individuals and within populations. Investigation into the genetic basis of cognition is a prominent area of research, with genetic associations being previously reported for a wide range of cognitive phenotypes. Here we utilise a genome-wide association study (GWAS) approach to evaluate the contribution of genetic variation to learning and memory phenotypes in a comprehensively phenotyped, well-characterised, healthy, and unrelated cohort of individuals (n = 613). Cognitive phenotypes were assessed using nine comprehensive test batteries consisting of twenty-one cognitive performance assessments including IQ, five measures for visual and verbal learning, a


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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Supplements

  • thiamine (vitamin B1) Low

    SLC19A3 encodes a thiamine transporter; G allele associates with lower learning and memory scores; thiamine deficiency impairs cognitive function and hippocampal neurogenesis

    discuss thiamine status with healthcare provider; consider 50-100 mg daily if deficient