rs12099085 - MARK2

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder. - Progress in neuro-psychopharmacology & biological psychiatry (2011) · Mick E, McGough JJ, Middleton FA, Neale B, Faraone SV · PubMed 21130132

  We conducted a genome-wide association study of blood pressure in an open-label study of the methylphenidate transdermal system (MTS) for the treatment of attention-deficit/hyperactivity disorder (ADHD). Genotyping was conducted with the Affymetrix Genome-Wide Human SNP Array 6.0. Multivariate association analyses were conducted using the software package PLINK. After data cleaning and quality control we tested 316,934 SNPs in 140 children with ADHD. We observed no genome-wide statistically significant findings, but a SNP in a K(+)-dependent Na(+)/Ca(2+) exchanger expressed in vascular smooth muscle (SLC24A3) was included in our top associations at p<1E-04. Genetic enrichment analyses of genes with ≥1 SNP significant at p<0.01, implicated several functional categories (FERM domain, p=5.0

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