rs12094148 - LINC01677 - MTATP6P14

Magnitude 2.2 · 1 study on file

Reported associations

• A genome-wide association study for highly sensitive cardiac troponin T levels identified a novel genetic variation near a RBAK-ZNF890P locus in the Japanese general population. - International journal of cardiology (2021) · Nasu T, Satoh M, Hachiya T, Sutoh Y, Ohmomo H, Hitomi S, Taguchi S, Kikuchi H, Kobayashi T, Takahashi Y, Osaki T, Morino Y, Sobue K, Shimizu A, Sasaki M · PubMed 33321125

  Cardiovascular disease (CVD) is a major cause of mortality worldwide. High-sensitivity cardiac troponin T (hs-cTnT) is released into the bloodstream due to cardiomyocyte damage and is associated with a high CVD risk. This study aimed to investigate hs-cTnT-related genetic variation and to examine whether this is an associated risk factor for CVD in the Japanese general population. This was a genome-wide association study (GWAS) based on a cohort from the 2013 Tohoku Medical Megabank Project community study. The GWAS was performed using a HumanOmniExpressExome BeadChip array with 914,035 autosomal single-nucleotide polymorphisms. The Framingham Risk Score and the Suita score were used to evaluate the future risk of CVD. The GWAS identified 10 loci reaching suggestive significance in the dis

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