rs12092137 - NOTCH2
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Refined carbohydrate intake Moderate
NOTCH2 downregulated in pancreatic tissue; affects insulin secretion and glucose metabolism
Monitor blood glucose response to meals; limit refined carbs
Discuss with your doctor
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Personalized diabetes risk assessment and screening Moderate
Very strong genetic association with elevated HbA1c (p=9e-18); warrants professional risk evaluation
Exercise
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Aerobic exercise for glucose control Moderate
Exercise improves insulin sensitivity to compensate for NOTCH2-mediated glucose dysregulation
150 minutes moderate-intensity aerobic exercise weekly
Screening
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HbA1c and fasting glucose screening Moderate
Variant associated with elevated HbA1c (p=9e-18 in 492k-person GWAS)
Baseline HbA1c; repeat annually