rs12089980 - CCDST - LCE5A

Magnitude 2.2 · 1 study on file

Reported associations

• Identification of OCA2 as a novel locus for the co-morbidity of asthma-plus-eczema. - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2022) · Margaritte-Jeannin P, Budu-Aggrey A, Ege M, Madore AM, Linhard C, Mohamdi H, von Mutius E, Granell R, Demenais F, Laprise C, Bouzigon E, Dizier MH · PubMed 34155719

  Numerous genes have been associated with the three most common allergic diseases (asthma, allergic rhinitis or eczema) but these genes explain only a part of the heritability. In the vast majority of genetic studies, complex phenotypes such as co-morbidity of two of these diseases, have not been considered. This may partly explain missing heritability. To identify genetic variants specifically associated with the co-morbidity of asthma-plus-eczema. We first conducted a meta-analysis of four GWAS (Genome-Wide Association Study) of the combined asthma-plus-eczema phenotype (total of 8807 European-ancestry subjects of whom 1208 subjects had both asthma and eczema). To assess whether the association with SNP(s) was specific to the co-morbidity, we also conducted a meta-analysis of homogeneity

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