rs12085650 - PUM1
Magnitude 2.8 · 1 study on file
Reported associations
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Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program - Unknown journal (n.d.) · Unknown authors · PubMed 38162683
ABSTRACT: Introduction: Apparent treatment-resistant hypertension (aTRH) is characterized by the use of four or more antihypertensive (AHT) classes to achieve blood pressure (BP) control. In the current study, we conducted single-variant and gene-based analyses of aTRH among individuals from 12 Trans-Omics for Precision Medicine cohorts with whole-genome sequencing data. Methods: Cases were defined as individuals treated for hypertension (HTN) taking three different AHT classes, with average systolic BP ≥ 140 or diastolic BP ≥ 90 mmHg, or four or more medications regardless of BP (n = 1,705). A normotensive control group was defined as individuals with BP < 140/90 mmHg (n = 22,079), not on AHT medication. A second control group comprised individuals who were treatment responsive on o
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic risk for treatment-resistant hypertension Moderate
GWAS data shows increased susceptibility to poor blood pressure control in A allele carriers
Discuss with primary care or cardiologist, especially if currently on antihypertensive therapy
Screening
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Blood pressure and antihypertensive medication response Moderate
rs12085650 A allele carriers show 30% increased odds of treatment-resistant hypertension
Annual blood pressure screening; assess medication efficacy if taking antihypertensives