rs12083390 - PIK3CD

Magnitude 2.2 · 1 study on file

Reported associations

• Social and non-social autism symptoms and trait domains are genetically dissociable - Unknown journal (n.d.) · Unknown authors · PubMed 31508503

  ABSTRACT: The core diagnostic criteria for autism comprise two symptom domains - social and communication difficulties, and unusually repetitive and restricted behaviour, interests and activities. There is some evidence to suggest that these two domains are dissociable, though this hypothesis has not yet been tested using molecular genetics. We test this using a genome-wide association study (N = 51,564) of a non-social trait related to autism, systemising, defined as the drive to analyse and build systems. We demonstrate that systemising is heritable and genetically correlated with autism. In contrast, we do not identify significant genetic correlations between social autistic traits and systemising. Supporting this, polygenic scores for systemising are significantly and positive

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