rs12081541 - CCDST - LCE5A
Magnitude 4.5 · 1 study on file
Reported associations
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Meta-analysis identifies seven susceptibility loci involved in the atopic march - Unknown journal (n.d.) · Unknown authors · PubMed 26542096
ABSTRACT: Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10−8) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10−9). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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early preventive skin moisturization with emollients Low
The variant associates with reduced skin barrier function via filaggrin pathway effects, increasing allergen transcutaneous penetration and promoting atopic disease progression
Daily emollient application to skin from birth, particularly after bathing; prior studies showed prevention benefit for early eczema
Screening
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early-onset eczema and childhood asthma development Moderate
Carriers have 1.6-fold increased genetic risk for atopic march, the sequential progression of early eczema to childhood asthma
Clinical assessment for eczema manifestations by age 3; monitor for asthma symptoms through age 16