rs12081070 - UBE2U

Magnitude 4.5 · 1 study on file

Reported associations

• Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis - Unknown journal (n.d.) · Unknown authors · PubMed 31092817

  ABSTRACT: Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. In a genome-wide association study of human and pathogen we show that human variation explains almost half of variation in susceptibility to pneumococcal meningitis and one-third of variation in severity, identifying variants in CCDC33 associated with susceptibility. Pneumococcal genetic variation explains a large amount of invasive potential (70%), but has no effect on severity. Serotype alone is insufficient to explain invasiveness, suggesting other pneumococcal factors are involved in progr

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