rs12078693 - RYR2
Magnitude 4.5 · 1 study on file
Reported associations
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Nightmares share genetic risk factors with sleep and psychiatric traits - Unknown journal (n.d.) · Unknown authors · PubMed 38413574
ABSTRACT: Nightmares are vivid, extended, and emotionally negative or negative dreams that awaken the dreamer. While sporadic nightmares and bad dreams are common and generally harmless, frequent nightmares often reflect underlying pathologies of emotional regulation. Indeed, insomnia, depression, anxiety, or alcohol use have been associated with nightmares in epidemiological and clinical studies. However, the connection between nightmares and their comorbidities are poorly understood. Our goal was to examine the genetic risk factors for nightmares and estimate correlation or causality between nightmares and comorbidities. We performed a genome-wide association study (GWAS) in 45,255 individuals using a questionnaire-based assessment on the frequency of nightmares during the past month and
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic risk factors for nightmares and sleep quality Moderate
RYR2 rs12078693 is associated with elevated nightmare risk; discussion enables targeted evaluation
Mention this genetic finding during routine visit or if nightmares are a concern
Lifestyle
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Sleep quality and nightmare frequency Moderate
RYR2 rs12078693 risk allele is significantly associated with nightmare occurrence
Track sleep patterns and nightmare occurrence weekly for 4-8 weeks