rs12063142 - PAX7 - TAS1R2

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease - Unknown journal (n.d.) · Unknown authors · PubMed 20070850

  ABSTRACT: SUMMARY Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative prevalence of greater than one per thousand. To date three independent genome-wide association studies (GWAS) have investigated the genetic susceptibility to PD. These studies have also implicated several genes as PD risk loci with strong, but not genome-wide significant, associations. In this study, we combined data from two previously published GWAS of Caucasian subjects with our GWAS of 604 cases and 619 controls for a joint analysis with a combined sample size of 1752 cases and 1745 controls. SNPs in SNCA (rs2736990, p-value = 6.7×10−8; genome-wide adjusted p = 0.0109, odds ratio (OR) = 1.29 [95% CI: 1.17-1.42] G vs. A allele, population attributable risk percent (PAR%) = 12%) and th

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