rs12061406 - PABPC4 - HEYL
Magnitude 2.2 · 1 study on file
Reported associations
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Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 30239722
ABSTRACT: Abstract More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess fat, rather than general adiposity, are more informative for predicting risk of obesity sequelae, including cardiometabolic disease and cancer. We performed a genome-wide association study meta-analysis of body fat distribution, measured by waist-to-hip ratio (WHR) adjusted for body mass index (WHRadjBMI), and identified 463 signals in 346 loci. Heritability and variant effects were generally stronger in women than men, and we found approximately one-third of all signals to be sexually dimorphic. The 5% of individuals carrying the most WHRadjBMI-increasing alleles were 1.62 times more likely than the bottom 5% to have a WHR
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Caloric intake and dietary composition Moderate
Dietary habits are a modifiable factor that influences body weight and can mitigate genetic BMI predisposition
Regular dietary awareness; consider tracking if overweight or attempting weight management
Exercise
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Regular aerobic physical activity Moderate
Physical activity counteracts genetic predisposition to elevated body mass and is a primary intervention for weight management
150 minutes of moderate-intensity aerobic activity per week as a target
Screening
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Body mass index and weight Moderate
rs12061406 T-allele is associated with increased body mass index in large population studies
Regular BMI and weight measurement, at least annually or more frequently if overweight