rs12058524 - VPS45
Magnitude 2.2 · 1 study on file
Reported associations
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A genome-wide association study of serum uric acid in African Americans - Unknown journal (n.d.) · Unknown authors · PubMed 21294900
ABSTRACT: Background Uric acid is the primary byproduct of purine metabolism. Hyperuricemia is associated with body mass index (BMI), sex, and multiple complex diseases including gout, hypertension (HTN), renal disease, and type 2 diabetes (T2D). Multiple genome-wide association studies (GWAS) in individuals of European ancestry (EA) have reported associations between serum uric acid levels (SUAL) and specific genomic loci. The purposes of this study were: 1) to replicate major signals reported in EA populations; and 2) to use the weak LD pattern in African ancestry population to better localize (fine-map) reported loci and 3) to explore the identification of novel findings cognizant of the moderate sample size. Methods African American (AA) participants (n = 1,017) from the Howard Univers
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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serum uric acid levels Moderate
rs12058524 T allele carriers have significantly elevated serum uric acid in association studies, a biomarker for gout and kidney disease risk
obtain serum uric acid measurement; if elevated per lab reference range, consider annual monitoring