rs1205312 - ASIP

Magnitude 2.8 · 1 study on file

Reported associations

• Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations - Unknown journal (n.d.) · Unknown authors · PubMed 40835838

  ABSTRACT: Keloids are raised scars that grow beyond original wound boundaries, resulting in pain and disfigurement. Reasons for keloid development are not well-understood, and current treatment options are limited. Keloids are more likely to occur in darker-skinned individuals of African and Asian descent than in Europeans. We performed a genome-wide association study (GWAS) examining keloid risk across and within continental ancestry groups, incorporating 7837 cases and 1,593,009 controls. We detected 26 loci in the multi-ancestry analysis, 12 of which replicated in an independent dataset. Heritability estimates were 6%, 21%, and 34% for the European, East Asian, and African ancestry analyses, respectively. Genetically predicted gene expression and colocalization analyses identified 27 ge

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