rs12052359 - RNA5SP99 - RN7SL201P

Magnitude 2.2 · 1 study on file

Reported associations

• UGT1A1 is a major locus influencing bilirubin levels in African Americans - Unknown journal (n.d.) · Unknown authors · PubMed 22085899

  ABSTRACT: Total serum bilirubin is associated with several clinical outcomes, including cardiovascular disease, diabetes and drug metabolism. We conducted a genome-wide association study in 619 healthy unrelated African Americans in an attempt to replicate reported findings in Europeans and Asians and to identify novel loci influencing total serum bilirubin levels. We analyzed a dense panel of over two million genotyped and imputed SNPs in additive genetic models adjusting for age, sex, and the first two significant principal components from the sample covariance matrix of genotypes. Thirty-nine SNPs spanning a 78 kb region within the UGT1A1 displayed P-values <5 × 10−8. The lowest P-value was 1.7 × 10−22 for SNP rs887829. None of SNPs in the UGT1A1 remained statistically significa

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