Expressive

rs12048727 - ZRANB2-DT

Magnitude 2.2 · 3 studies on file

Reported associations

  • Genome-wide meta-analyses of cross substance use disorders in diverse populations - Unknown journal (n.d.) · Unknown authors · PubMed 41057643

    ABSTRACT: Substance use disorders (SUDs, including alcohol, cannabis, opioids, and tobacco) represent significant public health challenges. The estimated heritability of SUDs is ~50% and many individuals experience multiple SUDs concurrently. Studies have demonstrated the existence of genes shared across multiple SUDs, and identifying these SUD-shared genes is critical to developing novel prevention and treatment strategies. Here, we conducted the largest cross SUD meta-analysis to date to identify SUD-shared genes using samples genetically similar to 1000 Genomes Project European (1kg-EUR-like), African (1kg-AFR-like), and American mixed (1kg-AMR-like) populations. We defined variants that had the same direction of effects across different SUDs (i.e., concordant variants) as SUD-shared. I

  • Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder - Unknown journal (n.d.) · Unknown authors · PubMed 36301540

    ABSTRACT: Key Points Question What is the genetic architecture of maximum habitual alcohol intake (MaxAlc), and how does it compare with other alcohol consumption measures? Findings This genetic association study of MaxAlc in 247 455 European- and African-ancestry individuals identified 15 genome-wide significant loci, including multiple novel associations. MaxAlc was genetically correlated with measures of alcohol-related problems, demonstrated significantly different correlations with psychiatric traits compared with other alcohol consumption traits, and loaded on a factor with alcohol problem traits, while alcohol consumption measures loaded on a separate factor. Meaning These findings suggest that MaxAlc is genetically different from consumption measures in relation to problematic al

  • Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits - Unknown journal (n.d.) · Unknown authors · PubMed 32451486

    ABSTRACT: Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although genome-wide association studies (GWASs) have identified PAU risk genes, the genetic architecture of this trait is not fully understood. We conducted a proxy-phenotype meta-analysis of PAU combining alcohol use disorder and problematic drinking in 435,563 European-ancestry individuals. We identified 29 independent risk variants, 19 of them novel. PAU was genetically correlated with 138 phenotypes, including substance use and psychiatric traits. Phenome-wide polygenic risk score analysis in an independent biobank sample (BioVU, n=67,589) confirmed the genetic correlations between PAU and substance use and psychiatric disorders. Genetic heritability of PAU was enriched in brain and in conser

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