Expressive

rs12047417 - IL22RA1

Magnitude 2.2 · 1 study on file

Reported associations

  • A cross-population atlas of genetic associations for 220 human phenotypes. - Nature genetics (2021) · Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A, Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y · PubMed 34594039

    Current genome-wide association studies do not yet capture sufficient diversity in populations and scope of phenotypes. To expand an atlas of genetic associations in non-European populations, we conducted 220 deep-phenotype genome-wide association studies (diseases, biomarkers and medication usage) in BioBank Japan (n = 179,000), by incorporating past medical history and text-mining of electronic medical records. Meta-analyses with the UK Biobank and FinnGen (n = 628,000) identified ~5,000 new loci, which improved the resolution of the genomic map of human traits. This atlas elucidated the landscape of pleiotropy as represented by the major histocompatibility complex locus, where we conducted HLA fine-mapping. Finally, we performed statistical decomposition of matrices of phenome-wid

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Anti-inflammatory diet pattern Moderate

    Elevated CRP is linked to genetic predisposition in rs12047417 A allele carriers; dietary patterns rich in antioxidants and omega-3s reduce CRP

    Mediterranean diet pattern: emphasize vegetables, fruits, whole grains, fish, olive oil; limit processed foods

Discuss with your doctor

  • Cardiovascular risk assessment and management Moderate

    rs12047417 A allele carriers have genetically elevated CRP, an independent cardiovascular risk factor requiring personalized risk assessment

Exercise

  • Regular aerobic exercise for CRP reduction Moderate

    Aerobic exercise is a proven strategy for reducing CRP; particularly beneficial for those with genetic predisposition to elevated CRP

    Aim for 150 minutes moderate-intensity aerobic activity per week

Screening

  • C-reactive protein testing Moderate

    rs12047417 A allele is associated with elevated C-reactive protein, an inflammatory marker linked to cardiovascular and metabolic disease risk

    Obtain baseline CRP test; repeat annually or per clinical indication