rs12046117 - VTCN1

Magnitude 4.5 · 1 study on file

Reported associations

• Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis - Unknown journal (n.d.) · Unknown authors · PubMed 19116933

  ABSTRACT: Objective Juvenile idiopathic arthritis (JIA) is a chronic rheumatic disease of childhood. Two well-established genetic factors known to contribute to JIA susceptibility, HLA and PTPN22, account for less than half of the genetic susceptibility to disease; therefore, additional genetic factors have yet to be identified. The purpose of this study was to perform a systematic search of the genome to identify novel susceptibility loci for JIA. Methods A genome-wide association study using Affymetrix GeneChip 100K arrays was performed in a discovery cohort (279 cases and 184 controls). Single-nucleotide polymorphisms (SNPs) showing the most significant differences between cases and controls were then genotyped in a validation sample of cases (n = 321) and controls, combined with contro

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