rs12045923 - PEX14
Magnitude 2.2 · 1 study on file
Reported associations
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Eleven loci with new reproducible genetic associations with allergic disease risk - Unknown journal (n.d.) · Unknown authors · PubMed 29679657
ABSTRACT: Background A recent genome-wide association study (GWAS) identified 99 loci that contain genetic risk variants shared between asthma, hay fever and eczema. Many more risk loci shared between these common allergic diseases remain to be discovered, which could point to new therapeutic opportunities. Objective To identify novel risk loci shared between asthma, hay fever and eczema by applying a gene-based test of association to results from a published GWAS that included data from 360,838 individuals. Methods We used approximate conditional analysis to adjust the results from the published GWAS for the effects of the top risk variants identified in that study. We then analysed the adjusted GWAS results with the EUGENE gene-based approach, which combines evidence for association with
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic risk for allergic disease Moderate
CASZ1 variant associated with increased susceptibility to asthma, hay fever, and eczema; identified in genome-wide study of 360,838 individuals.
Discuss with healthcare provider to evaluate personal and family allergy history and determine if preventive screening is warranted.