rs12045035 - LINC02869
Magnitude 2.2 · 1 study on file
Reported associations
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A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 26634245
ABSTRACT: Background Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed a genome-wide association study (GWAS) in 9919 current and former smokers in the COPDGene study (6659 non-Hispanic Whites [NHW] and 3260 African Americans [AA]) to identify associations with spirometric measures (post-bronchodilator FEV1 and FEV1/FVC). We also conducted meta-analysis of FEV1 and FEV1/FVC GWAS in the COPDGene, ECLIPSE, and GenKOLS cohorts (total n = 13,532). Results Among NHW in the COPDGene cohort, both measures of pulmonary function were significantly associated with SNPs at the 15q25 locus [containing CHRNA3/5, AGPHD1, IREB2, CHRNB4] (low
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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baseline spirometry assessment Moderate
Variant A allele at rs12045035 associates with altered post-bronchodilator FEV1/FVC ratio (GWAS p=9e-7, n=13,532), a marker of airway obstruction.
Discuss baseline spirometry testing with your healthcare provider to establish reference lung function values.