rs12042302 - ESRRG - GPATCH2

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic heterogeneity in self-reported depressive symptoms identified through genetic analyses of the PHQ-9. - Psychological medicine (2021) · Thorp JG, Marees AT, Ong JS, An J, MacGregor S, Derks EM · PubMed 31530331

  Depression is a clinically heterogeneous disorder. Previous large-scale genetic studies of depression have explored genetic risk factors of depression case-control status or aggregated sums of depressive symptoms, ignoring possible clinical or genetic heterogeneity. We analyse data from 148 752 subjects of white British ancestry in the UK Biobank who completed nine items of a self-rated measure of current depressive symptoms: the Patient Health Questionnaire (PHQ-9). Genome-Wide Association analyses were conducted for nine symptoms and two composite measures. LD Score Regression was used to calculate SNP-based heritability (h2SNP) and genetic correlations (rg) across symptoms and to investigate genetic correlations with 25 external phenotypes. Genomic structural equation modelling was used

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