rs12041884 - RYR2

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-Wide Association Study of Sleep Disturbances in Depressive Disorders. - Molecular neuropsychiatry (2022) · Melhuish Beaupre LM, Gonçalves VF, Zai CC, Tiwari AK, Harripaul RS, Herbert D, Freeman N, Müller DJ, Kennedy JL · PubMed 32399468

  Sleep disturbance affects about 75% of depressed individuals and is associated with poorer patient outcomes. The genetics in this field is an emerging area of research. Thus far, only core circadian genes have been examined in this context. We expanded on this by performing a genome-wide association study (GWAS) followed by a preplanned hypothesis-driven analysis with 27 genes associated with the biology of sleep. All participants were diagnosed by their referring physician, completed the Beck Depression Inventory (BDI), and the Udvalg for Kliniske Undersogelser Side Effect Rating Scale at baseline. Our phenotype consisted of replies to 3 questions from these questionnaires. From standard GWAS chip data, imputations were performed. Baseline total BDI scores ( = 364) differed significantly

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