rs12041852 - TNNI3K, FPGT-TNNI3K

Magnitude 2.2 · 2 studies on file

Reported associations

• Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. - Human molecular genetics (2016) · Felix JF, Bradfield JP, Monnereau C, van der Valk RJ, Stergiakouli E, Chesi A, Gaillard R, Feenstra B, Thiering E, Kreiner-Møller E, Mahajan A, Pitkänen N, Joro R, Cavadino A, Huikari V, Franks S, Groen-Blokhuis MM, Cousminer DL, Marsh JA, Lehtimäki T, Curtin JA, Vioque J, Ahluwalia TS, Myhre R, Price TS, Vilor-Tejedor N, Yengo L, Grarup N, Ntalla I, Ang W, Atalay M, Bisgaard H, Blakemore AI, Bonnefond A, Carstensen L, Eriksson J, Flexeder C, Franke L, Geller F, Geserick M, Hartikainen AL, Haworth CM, Hirschhorn JN, Hofman A, Holm JC, Horikoshi M, Hottenga JJ, Huang J, Kadarmideen HN, Kähönen M, Kiess W, Lakka HM, Lakka TA, Lewin AM, Liang L, Lyytikäinen LP, Ma B, Magnus P, McCormack SE, McMahon G, Mentch FD, Middeldorp CM, Murray CS, Pahkala K, Pers TH, Pfäffle R, Postma DS, Power C, Simpson A, Sengpiel V, Tiesler CM, Torrent M, Uitterlinden AG, van Meurs JB, Vinding R, Waage J, Wardle J, Zeggini E, Zemel BS, Dedoussis GV, Pedersen O, Froguel P, Sunyer J, Plomin R, Jacobsson B, Hansen T, Gonzalez JR, Custovic A, Raitakari OT, Pennell CE, Widén E, Boomsma DI, Koppelman GH, Sebert S, Järvelin MR, Hyppönen E, McCarthy MI, Lindi V, Harri N, Körner A, Bønnelykke K, Heinrich J, Melbye M, Rivadeneira F, Hakonarson H, Ring SM, Smith GD, Sørensen TI, Timpson NJ, Grant SF, Jaddoe VW · PubMed 26604143

  A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (P-value < 5 × 10(-8)) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 nea

• A Genome-Wide Association Study of Childhood Body Fatness - Unknown journal (n.d.) · Unknown authors · PubMed 33491310

  ABSTRACT: Objective: To uncover genetic contributors to adiposity in early-life. Methods: We conducted a genome-wide association study (GWAS) of childhood body fatness in 34,401 individuals within the Nurses' Health Studies and the Health Professionals Follow-up Study. We imputed using the 1000 Genomes Phase 3 v5 reference panel. Results: We identified 1,354 SNPs (p<10−4) from a previously published GWAS of childhood body mass index (BMI). We observed 19 genome-wide significant (p<5x 10−8) regions, of which 14 were previously associated with childhood obesity, while five were novel: BNDF (p= 7.58 x 10−13), PRKD1 (p= 1.43 x10−10), 20p13 (p= 2.05 x10−10), FHIT (p= 1.77 x10−08), and LOC101927575 (p=3.22 x 10−08). The BNDF, FHIT and PRKD1 regions were previously associated with

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