rs12040273 - GALNT2

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort. - Atherosclerosis (2016) · Xie G, Myint PK, Voora D, Laskowitz DT, Shi P, Ren F, Wang H, Yang Y, Huo Y, Gao W, Wu Y · PubMed 26343869

  Carotid artery intima media thickness (IMT) in human is a marker of subclinical atherosclerosis with high heritability. Many genome-wide association studies (GWAS) were performed in European and American populations, yet discovery efforts have been limited in Asians. To identify the genetic determinants of 10-year progression of IMT using GWA approach in a Chinese cohort. Cardiovascular epidemiologic survey was carried out in 810 Chinese adults in 2012. 302,218 single-nucleotide polymorphisms (SNP) in whole genome were genotyped using gene chip and carotid IMT was measured. Most of these participants, had previous carotid IMT measurements in 2002 (n = 572), 2005 (n = 750), 2007 (n = 747), and 2010 (n = 671). General linear model (GLM) and multiple linear mixed-model (MLM) were used to asse

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