rs12037343 - U3 - NXNP1
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries - Unknown journal (n.d.) · Unknown authors · PubMed 24556642
ABSTRACT: Dental caries continues to be the most common chronic disease in children today. Despite the substantial involvement of genetics in the process of caries development, the specific genes contributing to dental caries remain largely unknown. We performed separate genome-wide association studies of smooth and pit-and-fissure tooth surface caries experience in the primary dentitions of self-reported white children in two samples from Iowa and rural Appalachia. In total, 1006 children (ages 3-12 years) were included for smooth surface analysis, and 979 children (ages 4-14 years) for pit-and-fissure surface analysis. Associations were tested for more than 1.2 million single nucleotide polymorphisms, either genotyped or imputed. We detected genome-wide significant signals in KPNA4 (p-va
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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frequent sugary foods and beverages between meals Moderate
NXNP1-T increases caries risk; dietary fermentable carbohydrates enhance plaque acid production
limit sugary snacks and drinks to mealtimes; rinse mouth after sugar consumption
Lifestyle
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fluoride toothpaste and daily flossing Moderate
NXNP1-T increases caries susceptibility; fluoride and mechanical plaque removal mitigate risk
brush twice daily with fluoride toothpaste and floss daily
Screening
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dental caries screening every 6 months Moderate
NXNP1 rs12037343-T allele associates with 2.2-fold increased odds of smooth-surface caries
schedule professional dental exams every 6 months