rs12036147 - CHRM3

Magnitude 2.0 · 1 study on file

Reported associations

• GWAS and Systems Biology Analysis of Depressive Symptoms among Smokers from the COPDGene Cohort - Unknown journal (n.d.) · Unknown authors · PubMed 30219690

  ABSTRACT: Background: Large sample GWAS is needed to identify genetic factors associated with depression. This study used genome-wide genotypic and phenotypic data from the COPDGene study to identify genetic risk factors for depression. Methods: Data were from 9,716 COPDGene subjects with ≥ 10 pack-year history. Depression was defined as antidepressant use and/or a HADS depression subscale score ≥ 8. Non-Hispanic White (6,576) and African-American (3,140) subsets were analyzed. A GWAS pipeline identified SNPs associated with depression in each group. Network analysis software analyzed gene interactions through common biological pathways, genetic interactions, and tissue-specific gene expression. Results: The mean age was 59.4 years (SD 9.0) with 46.5% female subjects. Depression was in

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