rs12034588 - AKT3
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic diversity fuels gene discovery for tobacco and alcohol use - Unknown journal (n.d.) · Unknown authors · PubMed 36477530
ABSTRACT: Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury. These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries. Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in s
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to smoking initiation Moderate
Strong GWAS association (p=3.00e-28, n=2.67M) indicates significant genetic component to smoking susceptibility
Inform healthcare provider to tailor smoking cessation support if needed
Lifestyle
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smoking due to genetic susceptibility Moderate
rs12034588 A allele increases susceptibility to smoking initiation through altered AKT3 signaling
Do not initiate smoking; if currently smoking, pursue evidence-based cessation strategies
Screening
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smoking-related disease screening Moderate
rs12034588 A allele increases risk of smoking initiation, requiring vigilance for smoking-related complications
Screen per guidelines for lung cancer, cardiovascular disease, and chronic obstructive pulmonary disease