rs12032381 - LINC02817 - DUSP10
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-Wide Association Scan of Dupuytren's Disease - Unknown journal (n.d.) · Unknown authors · PubMed 20971583
ABSTRACT: Purpose Dupuytren's disease (DD) has strong genetic component that is suggested by population studies and family clustering. Genetic studies have yet to identify the gene(s) involved in DD. The purpose of this study was to identify regions of the entire genome (Chromosome 1 - 23) associated with the disease by performing a genome-wide association scan (GWAS) on DD patients and controls. Methods Genomic DNA (gDNA) was isolated from saliva collected from 40 unrelated DD patients and 40 unaffected controls. The genotyping was conducted using CytoSNP™ - Infinium® HD Ultra genotyping assay on the Illumina platform. The single nucleotides polymorphism (SNP) genotyping data was analyzed using both log regression and mapping by admixture linkage disequilibrium (MALD) analysis method
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Dupuytren's disease surveillance Low
rs12032381 C allele confers 6.2-fold increased odds of Dupuytren's disease, a progressive fibroproliferative palmar disorder.
Annual hand examination for palmar nodules, cords, or flexion contracture