rs12031875 - ZRANB2-DT

Magnitude 2.2 · 1 study on file

Reported associations

• Novel alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders - Unknown journal (n.d.) · Unknown authors · PubMed 31358974

  ABSTRACT: Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a meta-analysis of genome-wide association studies (GWAS) of gram/day (g/d) alcohol consumption in UK-Biobank, AlcGen and CHARGE+ consortia accumulating 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigated their potential functional significance using magnetic resonance imaging data and gene expression studies. Our results identify genetic pathways associated with alcohol consumption and suggest shared genetic mechanisms with neuropsychiatric disorders including schizophrenia. FULL TEXT: [INTRO] Excessive alcohol consumption is a major p

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