rs12030482 - EEF1A1P11 - RN7SL831P
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways. - Nature genetics (2019) · Jansen PR, Watanabe K, Stringer S, Skene N, Bryois J, Hammerschlag AR, de Leeuw CA, Benjamins JS, Muñoz-Manchado AB, Nagel M, Savage JE, Tiemeier H, White T, Tung JY, Hinds DA, Vacic V, Wang X, Sullivan PF, van der Sluis S, Polderman TJC, Smit AB, Hjerling-Leffler J, Van Someren EJW, Posthuma D · PubMed 30804565
Insomnia is the second most prevalent mental disorder, with no sufficient treatment available. Despite substantial heritability, insight into the associated genes and neurobiological pathways remains limited. Here, we use a large genetic association sample (n = 1,331,010) to detect novel loci and gain insight into the pathways, tissue and cell types involved in insomnia complaints. We identify 202 loci implicating 956 genes through positional, expression quantitative trait loci, and chromatin mapping. The meta-analysis explained 2.6% of the variance. We show gene set enrichments for the axonal part of neurons, cortical and subcortical tissues, and specific cell types, including striatal, hypothalamic, and claustrum neurons. We found considerable genetic correlations with psychiatric tr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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evening caffeine Moderate
Caffeine can exacerbate sleep susceptibility; individuals with genetic predisposition may be particularly sensitive
Avoid caffeine after 2 PM, maximum 200mg before noon
Discuss with your doctor
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insomnia screening and CBT-I consideration Moderate
Genetic predisposition to insomnia warrants proactive sleep medicine evaluation
Discuss with primary care or sleep medicine specialist, consider CBT-I if insomnia symptoms develop
Exercise
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regular aerobic exercise (morning/afternoon timing) Moderate
Exercise improves sleep quality; morning/afternoon timing avoids sleep disruption, particularly important for genetically predisposed individuals
30 minutes moderate aerobic activity, scheduled before 4 PM, at least 5 days per week
Lifestyle
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sleep hygiene optimization Moderate
Consistent sleep-wake timing and sleep environment optimization may reduce genetic predisposition to insomnia
Maintain consistent bedtime/wake time, keep bedroom cool dark quiet, limit evening screen time after 9 PM
Screening
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sleep quality assessment Moderate
Genetic variant associated with 4.2% increased insomnia risk in large GWAS
Annual sleep quality assessment, consider polysomnography if symptoms develop