rs12027035 - FIRRM

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study revealed novel candidate gene loci associated with soluble E-selectin levels in a Taiwanese population. - Atherosclerosis (2025) · Teng MS, Hsu LA, Wu S, Tzeng IS, Chou HH, Ko YL · PubMed 34757267

  Increase soluble E-selectin (sE-selectin) levels are associated with various inflammation and cardiometabolic disorders. This study aimed to investigate the genetic determinants of circulating sE-selectin levels by genome-wide association study (GWAS) in 4,525 Taiwan Biobank (TWB) participants and genotype-phenotype association analysis for sE-selectin level-determining alleles in over 80,000 TWB participants. By GWAS, ABO, SELE, and FUT6 gene variants were identified as the determinants of sE-selectin levels, which reach genome-wide significance (maximum p = 3.25 × 10 , 4.81 × 10 , and 9.64 × 10 , respectively). After further adjustment for the lead ABO rs2519093 genotypes, three novel gene loci, EVI5, FER and DMAC1, were associated with sE-selectin levels at p < 5 × 10 . Th

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