Expressive

rs12025137 - LINC01787 - UBE2WP1

Magnitude 2.0 · 2 studies on file

Reported associations

  • Shared genetics between classes of obesity and psychiatric disorders: A large-scale genome-wide cross-trait analysis. - Journal of psychosomatic research (2022) · Ding H, Ouyang M, Wang J, Xie M, Huang Y, Yuan F, Jia Y, Zhang X, Liu N, Zhang N · PubMed 36137488

    Epidemiological studies demonstrate an association between classes of obesity and psychiatric disorders, although little is known about shared genetics and causality of association. Thus, we aimed to investigate shared genetics and causal link between different classes of obesity and psychiatric disorders. We used genome-wide association study (GWAS) summary data range from 9725 to 500,199 sample sizes of European descent, conducted a large-scale genome-wide cross-trait association study to investigate genetic overlap between the classes of obesity and anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, obsessive-compulsive disorder, schizophrenia, anxiety disorders and Tourette syndrome. We conducted transcript

  • Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS - Nature genetics (2021) · Peyrot WJ, Price AL · PubMed 33686288

    ABSTRACT: Psychiatric disorders are highly genetically correlated, but little research has been conducted on the genetic differences between disorders. We developed a new method (CC-GWAS) to test for differences in allele frequency among cases of two disorders using summary statistics from the respective case-control GWAS, transcending current methods that require individual-level data. Simulations and analytical computations confirm that CC-GWAS is well-powered with effective control of type I error. We applied CC-GWAS to publicly available summary statistics for schizophrenia, bipolar disorder, major depressive disorder, and five other psychiatric disorders. CC-GWAS identified 196 independent case-case loci, including 72 CC-GWAS-specific loci that were not genome-wide significant in the

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